AnatomyLesson 3 of 3 in the course Bone Tissue and the Skeletal System

Bone Ossification, Growth, Remodeling, and Osteogenesis Imperfecta

5 flashcards · 5 quiz questions · 5 match pairs · 5 fill-in sentences · English

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Summary

Bone development begins before birth, when the embryonic skeleton is made mostly of fibrous membranes and hyaline cartilage. This lesson introduces ossification and the cartilage templates used in skeletal development, then explains how intramembranous ossification forms certain bones directly from connective tissue.

Ossification, also called osteogenesis, is the process of bone formation. It begins around the sixth or seventh week of embryonic life. Bone is a replacement tissue: it forms by depositing mineralized matrix on a model or template. The template used most often in skeletal development is cartilage.

All flashcards

Ossification
Bone formation; also called osteogenesis.
Avascular cartilage
Cartilage without its own blood vessels; it relies on diffusion for nutrient and waste exchange.
Primary and secondary ossification centers
The primary center forms in the diaphysis; secondary centers form in the epiphyses, generally after birth.
Modeling versus remodeling
Modeling changes bone shape or size through activity on different surfaces; remodeling replaces bone on the same surface.
Osteogenesis imperfecta
A genetic condition affecting collagen production and causing fragile bones.

Quiz questions

  1. In endochondral ossification, what happens to the cartilage model?Answer: It is gradually removed and replaced by newly formed bone.
  2. Where does the primary ossification center usually develop in a growing long bone?Answer: Deep within the periosteal collar in the diaphysis.
  3. In which epiphyseal plate zone do chondrocytes divide and form stacks?Answer: The proliferative zone.
  4. During bone remodeling, how are resorption and new bone deposition related?Answer: They occur on the same surface as old or damaged bone is replaced.
  5. What underlying production problem causes osteogenesis imperfecta?Answer: A genetic mutation affects the body's production of collagen.

Based on Anatomy and Physiology 2e by J. Gordon Betts, Kelly A. Young, James A. Wise, Eddie Johnson, Brandon Poe, Dean H. Kruse, Oksana Korol, Jody E. Johnson, Mark Womble, Peter DeSaix (OpenStax), licensed CC BY 4.0. Adapted into a summary, flashcards and quizzes.

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