NeuroscienceLesson 1 of 1 in the course The Nervous System and Nervous Tissue

Ion Gradients, Action Potentials, and Axonal Conduction

5 flashcards · 5 quiz questions · 5 match pairs · 4 fill-in sentences · English

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Summary

Neurons communicate by changing the electrical state of their membranes. This lesson introduces the membrane structures and ion channels that make those changes possible.

The cell membrane is a phospholipid bilayer. Its hydrophobic interior prevents charged, hydrophilic ions from passing through unaided. Transmembrane proteins provide pathways through this barrier. Ion movement through these pathways is essential for establishing membrane voltage and generating electrical signals.

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What is continuous conduction?
Sequential activation of adjacent membrane regions along an unmyelinated axon.
What is saltatory conduction?
Propagation in a myelinated axon by regenerating action potentials at successive nodes of Ranvier.
What does all-or-none signaling mean for an action potential?
Once threshold is reached, the action potential follows its characteristic course; a stronger stimulus does not enlarge it.
What happens during the absolute refractory period?
Another action potential cannot be initiated because many voltage-gated Na⁺ channels are inactivated.
How do astrocytes help support neuronal signaling?
They buffer excess extracellular K⁺ and help maintain the chemical environment around neurons.

Quiz questions

  1. A neuron at rest has an approximate membrane potential of −70 mV. What does this value mean?Answer: The inside is about 70 mV more negative than the outside.
  2. At approximately what membrane potential does a typical neuron reach threshold for initiating an action potential?Answer: About −55 mV.
  3. What happens to a voltage-gated Na⁺ channel near the peak of an action potential?Answer: Its inactivation gate closes, stopping further Na⁺ entry.
  4. During which refractory period can another action potential not be initiated?Answer: The absolute refractory period.
  5. How does an action potential propagate along a myelinated axon?Answer: It is regenerated at successive nodes of Ranvier.

Based on Anatomy and Physiology 2e by J. Gordon Betts, Kelly A. Young, James A. Wise, Eddie Johnson, Brandon Poe, Dean H. Kruse, Oksana Korol, Jody E. Johnson, Mark Womble, Peter DeSaix (OpenStax), licensed CC BY 4.0. Adapted into a summary, flashcards and quizzes.

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